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Mitochodrial DNA Case-Control Association
Studies. Estimation of the Statistical Power
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Power estimation
|
A posteriori
power estimation
|
Sample size
|
Minimum difference
|
Minimum difference
Frequency of risky haplogroup/SNP variant (
p
0
)
It must be positive and less than 1
Sample size in controls
Is it a vector?
It must be positive and integer
Minimum sample size (
N
co,min
)
Maximum sample size (
N
co,max
)
Step
N
co,min
,
N
co,max
and Step must be positive and integer
For computational reasons, Step should be a number higher than (
N
co,max
-
N
co,min
) x 0.05
Sample size in cases
Is it a vector?
It must be positive and integer
Minimum sample size (
N
ca,min
)
Maximum sample size (
N
ca,max
)
Step
N
ca,min
,
N
ca,max
and Step must be positive and integer
For computational reasons, Step should be a number higher than (
N
ca,max
-
N
ca,min
) x 0.05
Total number of categories (
N
)
It must be positive and integer. The term categories refers to haplogroups or SNP variants (see examples for more information)
Significance level
0.1
0.05
0.01
0.005
0.001
A fixed value must be chosen
Desired power
95%
90%
85%
80%
75%
70%
65%
60%
55%
50%
A fixed value must be chosen
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